Let the salmon come to room temperature for 20 minutes. If your salmon fillets are on the thicker side and/or you like your salmon more well done, preheat oven to 400°F.
4 salmon fillets
Combine paprika, garlic powder, onion powder, cayenne pepper, dried oregano, dried thyme, salt and black pepper in a small bowl. Whisk to mix.
1 tablespoon sweet or smoked paprika, 1 teaspoon garlic powder, ¾ teaspoon onion powder, ½ teaspoon cayenne pepper, ½ teaspoon dried oregano, ½ teaspoon dried thyme, ½ teaspoon salt, ¼ teaspoon ground black pepper
Pat the salmon fillets dry with paper towels. Brush with melted butter and sprinkle generously with the seasonings, rubbing the seasonings onto the fish to help them stick.
2 tablespoons unsalted butter
(Ventilation is important, since blackened seasoning tends to smoke and this dish will smell fishy as it cooks. Turn on the stove hood fan and open a window.) Heat the oil in a large cast iron skillet over medium-high heat. Once the pan is very hot, turn the heat down to medium and add the salmon fillets, skin side up, to the pan. Cook on the first side for 2-3 minutes. The salmon is ready to flip when it has a nice golden brown crust and releases easily from the pan. Use a thin spatula to flip the fillets over so that they are skin side down.
1 ½ tablespoons avocado oil
Cook on the second side for 3-5 minutes, until the salmon reaches your desired doneness, 130-135°F in the center for medium, 145°F in the center is fully cooked. If it's not cooked to your liking after 5 minutes on the second side, finish cooking it in the oven until it reaches your desired doneness. Serve with lemon wedges.
1 lemon